The zinc finger antiviral protein (ZAP) is a host factor that mediates inhibition of viruses in the Filoviridae, Retroviridae and Togaviridae families.We previously demonstrated that ZAP blocks replication of Insulated Delivery Bags Sindbis virus (SINV), the prototype Alphavirus in the Togaviridae family at an early step prior to translation of the
Abstract Directed cell migration requires sustained cell polarisation.In migrating cortical interneurons, nuclear movements are directed towards the centrosome that organises the primary cilium signalling hub.Primary cilium-elicited signalling, and how it affects migration, Leggings remain however ill characterised.Here, we show that altering cAMP/
Abstract Background Neurokine signaling via the release of neurally active cytokines arises from glial reactivity and is mechanistically implicated in central nervous system (CNS) pathologies such as chronic pain, trauma, neurodegenerative diseases, and complex psychiatric illnesses.Despite significant advancements in the methodologies used to conj
Introduction: The prevalence of non-tuberculous mycobacteria (NTM) infection is increasing worldwide, presenting challenges for clinicians and microbiologists alike.This emerging infection is becoming more common in developed countries.While the clinical presentation of Mycobacterium tuberculosis complex (MTBC) and NTM may resemble each other, thei
Spectacular images Water Hose Coupler of the Afghan Pamirs tend to convey an impression of extreme remoteness and to conflate endangerment in perceptions of Afghan Kyrgyz migrations.But how can endangerment sensibilities meet the aesthetics of strategic mobilizations without downplaying contestation? In mobilizing text and images, this essay intend